Nursing psychological intervention in patients with acute myocardial infarction and its effect on quality of life / 中国生化药物杂志

Objective To analyze the effect of psychological care intervention combined with aspirin and tigrine in patients with acute myocardial infarction and its effect on quality of life. Methods A total of 82 patients with acute myocardial infarction were enrolled in our hospital from March 2016 to April 2017. The patients were divided into control group by random number table method and 41 patients in the experimental group. The patients in the control group were treated with aspirin and tigrilil. The study group increased the psychological nursing intervention on the basis of routine treatment, and analyzed the clinical symptom remission rate, complication rate and quality of life of the two groups. Results The remission rate and quality of life of the clinical group were significantly higher than those of the control group, and the complication rate was significantly lower than that of the control group (P<0.05). Conclusion The treatment of patients with acute myocardial infarction with psychological care combined with aspirin and tiereliluo treatment, can improve the clinical symptoms of remission rate, reduce complications, but also improve the quality of life, worthy of clinical application.

Nursing psychological intervention in patients with acute myocardial infarction and its effect on quality of life / 中国生化药物杂志

Objective To analyze the effect of psychological care intervention combined with aspirin and tigrine in patients with acute myocardial infarction and its effect on quality of life. Methods A total of 82 patients with acute myocardial infarction were enrolled in our hospital from March 2016 to April 2017. The patients were divided into control group by random number table method and 41 patients in the experimental group. The patients in the control group were treated with aspirin and tigrilil. The study group increased the psychological nursing intervention on the basis of routine treatment, and analyzed the clinical symptom remission rate, complication rate and quality of life of the two groups. Results The remission rate and quality of life of the clinical group were significantly higher than those of the control group, and the complication rate was significantly lower than that of the control group (P<0.05). Conclusion The treatment of patients with acute myocardial infarction with psychological care combined with aspirin and tiereliluo treatment, can improve the clinical symptoms of remission rate, reduce complications, but also improve the quality of life, worthy of clinical application.

Quinoline derivative PQ1 combined with cisplatin promotes the proliferation and gap junction communication of prostate cancer PC3 cells / 中华男科学杂志

<p><b>OBJECTIVE</b>To investigate the effects of the quinoline derivative PQ1 combined with cisplatin on the proliferation and gap junction communication of prostate cancer PC3 cells.</p><p><b>METHODS</b>We cultured in vitro prostate cancer PC3 cells and divided them into DMSO blank control, cisplatin control, and cisplatin (10 mg/ml) plus PQ1 (1, 2, 5, 10, and 15 μmol/L) groups. We measured the proliferation of the prostate cancer PC3 cells, determined the expressions of the connexin 43 (Cx43) mRNA and protein by RT-PCR and Western blot, and compared the indexes among different groups.</p><p><b>RESULTS</b>Cisplatin combined with PQl at 1 - 10 μmol/L significantly inhibited the proliferation of the PC3 cells and the inhibition rate rose in a concentration- and time-dependent manner, from (48.72 ± 0.98)% vs (50.33 ± 0.62)% at 0 μmol/L to (77.38 ± 1.12)% vs (83.50 ± 1.05)% at 15 μmol/L at 24 and 48 hours (P < 0.05). Compared with the cisplatin control, cisplatin combined with PQ1 at 1, 2, 5, 10, and 15 μmol/L increased the expression of Cx43 mRNA from 0.379 ± 0.113 to 0.669 ± 0.031, 0.831 ± 0. 127, 0.769 ± 0.100, 0.532 ± 0.086, and 0.475 ± 0.134, respectively (P < 0.05), and cisplatin combined with PQ1 at 1, 2, 5, and 10 μmol/L elevated that of Cx43 protein from 0.138 ± 0.146 to 0.263 ± 0.111, 0.306 ± 0.152, 0.415 ± 0.280, and 0.643 ± 0.310, respectively (P < 0.05).</p><p><b>CONCLUSION</b>The quinoline derivative PQ1 can promote the gap junction communication of prostate cancer PC3 cells and enhance the killing effect of cisplatin on PC3 cells by upregulating the expressions of Cx43 mRNA and protein.</p>

Risk factors of ISUP Modified Gleason score upgrading after radical prostatectomy / 中华男科学杂志

<p><b>OBJECTIVE</b>To investigate the factors upgrading the International Society of Urological Pathology (ISUP) Gleason score using the specimens from preoperative prostatic biopsy and radical prostatectomy.</p><p><b>METHODS</b>A total of 164 patients diagnosed with prostate cancer by biopsy underwent radical prostatectomy. We retrospectively analyzed their age, prostate volume, preoperative PSA level, PSA density (PSAD) , the time interval between biopsy and surgery, the number of positive punctures, positive surgical margin, seminal vesicle invasion, lymphatic invasion, and Gleason scores from biopsy and prostatectomy. We also determined the predictors of Gleason score upgrading by logistic regression analysis.</p><p><b>RESULTS</b>Of the 164 cases analyzed, 95 (57.93% ) showed a consistency between the Gleason score of preoperative prostatic biopsy and that after radical prostatectomy, 55 (33.54% ) increased and 14 (8.52%) decreased after prostatectomy as compared with preoperative biopsy. The prostate volume (P < 0.01) and biopsy score (P < 0.05) were independent predictors of Gleason score upgrading. The risk of Gleason score upgrading was 27 times higher in the patients with the prostate volume ≤ 25 ml and 9 times higher in the 25-40 ml group than in the > 60 ml group (P < 0.05).</p><p><b>CONCLUSION</b>Low Gleason score of biopsy (≤ 6) and small prostate volume (≤ 40 ml) may be the predictors of Gleason score upgrading after radical prostatectomy.</p>

Effect of low intensity white light irradiation on the retinas of mice / 国际眼科杂志(Guoji Yanke Zazhi)

AIM: To investigate the effect of low intensity white light irradiation on the retinas of mice. METHODS: Thirty C57BL/6J mice were randomly divided into two groups. The number of the mice in each group was 15. The mice in experimental group received dark adaptation from 5:00p. m. to 6:00p. m. , and then exposed to LED white light from 6:00p. m. to 7:00p. m. everyday for a month. At 1, 3, 7, 14 and 30d after the beginning, we examed the histology of mice retinas, calculated the thickness of outer nuclear layer ( ONL ) , inner nuclear layer ( INL ) and analyzed electrophysiology of mice. RESULTS:One month after experiment, compared to the control group, the latency of Rod-R a wave of the mice in experimental group significantly prolonged, the amplitude of Cone-R b wave of the mice in experimental group significantly decreased and the latency of b wave of the mice in experimental group significantly prolonged ( P CONCLUSION: 100lux low intensity white light could give rise to the impairment of the retinal functions in dark-adapted mice.